The acute effect of maximal exercise on arterial stiffness in adults with and without intellectual and developmental disabilities
Publication: Applied Physiology, Nutrition, and Metabolism
7 September 2022
Abstract
We compared central and peripheral arterial stiffness response patterns between persons with and without intellectual and developmental disabilities (IDD) of different age groups at rest and following a cardiopulmonary exercise test (CPET). Fifteen young adults with and without IDD, and 15 middle-aged adults without IDD performed a CPET. Central and peripheral arterial stiffness were measured at rest and following CPET using estimates of carotid-femoral (cfPWV), carotid-radial (crPWV), and carotid-ankle (cdPWV) pulse wave velocity derived from piezoelectric mechano-transducers. cfPWV remained unchanged following CPET in adults with and without IDD but increased in middle-aged adults (d = 0.85; 95% CI: 0.27–1.42 m·s–1, p = 0.005), whereas cdPWV was similarly reduced (d = –0.77; 95% CI: –1.06 to –0.48 m·s–1, p < 0.001) in all groups. crPWV remained unchanged in all groups. These results were independent of exercise-related changes in mean arterial pressure. Overall group differences suggested that persons with IDD (d = –1.78; 95% CI: –3.20 to –0.37 m·s–1, p = 0.009) and without IDD (d = –1.84; 95% CI: –3.26 to –0.43 m·s–1, p = 0.007) had lower cfPWV than middle-aged adults. We found no evidence of early vascular aging and diminished vascular reserve following CPET in adults with IDD.
Résumé
Nous avons comparé les schémas de réponse de la rigidité artérielle centrale et périphérique entre des personnes avec et sans déficience intellectuelle et développementale (« IDD ») de différents groupes d'âge au repos et après un test d'effort cardiopulmonaire (« CPET »). Quinze jeunes adultes avec et sans IDD et 15 adultes d'âge moyen sans IDD ont effectué un CPET. La rigidité artérielle centrale et périphérique a été mesurée au repos et après le CPET à l'aide d'estimations de la vitesse de l'onde de pouls carotide-fémorale (« cfPWV »), carotide-radiale (« crPWV ») et carotide-cheville (« cdPWV ») dérivée de mécano-transducteurs piézoélectriques. La cfPWV est demeurée inchangée après le CPET chez les adultes avec et sans IDD, mais a augmenté chez les adultes d'âge moyen (d = 0,85; IC à 95 % : 0,27 à 1,42 m·s–1, p = 0,005) tandis que la cdPWV a été réduite de manière similaire (d = –0,77; IC 95% : –1,06 à –0,48 m·s–1, p < 0,001) dans tous les groupes. La crPWV est restée inchangée dans tous les groupes. Ces résultats étaient indépendants des changements de la pression artérielle moyenne liés à l'exercice. Les différences globales entre les groupes suggèrent que les personnes avec IDD (d = –1,78; IC à 95 % : –3,20 à –0,37 m·s–1, p = 0,009) et sans IDD (d = –1,84; IC à 95 % : –3,26 à –0,43 m·s–1, p = 0,007) avaient une cfPWV inférieure à celle des adultes d'âge moyen. Nous n'avons relevé aucune donnée probante d'un vieillissement vasculaire précoce et d'une diminution de la réserve vasculaire à la suite d'un CPET chez des adultes avec IDD. [Traduit par la Rédaction]
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Applied Physiology, Nutrition, and Metabolism
Volume 47 • Number 10 • October 2022
Pages: 1005 - 1013
History
Received: 15 April 2022
Accepted: 8 July 2022
Accepted manuscript online: 12 July 2022
Version of record online: 7 September 2022
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© 2022 The Author(s). Permission for reuse (free in most cases) can be obtained from copyright.com.
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Data are available upon reasonable request.
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HSC and MC contributed to conception and design, critically revised the manuscript, and gave final approval. RP, VA, JR, DC, MR, and VS contributed to acquisition, analysis, critically revised the manuscript, and gave final approval. XM contributed to acquisition, analysis, interpretation, drafted the manuscript, and gave final approval. BF and JLM contributed to interpretation, critically revised the manuscript, and gave final approval.
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The authors have no conflict of interest. The authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.
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The authors declare no specific funding for this work.
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Xavier Melo, João Luís Marôco, Rita Pinto, Vitor Angarten, Manuel Coimbra, Duarte Correia, Mafalda Roque, Joana Reis, Vanessa Santos, Bo Fernhall, and Helena Santa-Clara. 2022. The acute effect of maximal exercise on arterial stiffness in adults with and without intellectual and developmental disabilities. Applied Physiology, Nutrition, and Metabolism.
47(10): 1005-1013. https://doi.org/10.1139/apnm-2022-0165
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