Nuclear receptor 4A1 (NR4A1), a member of the NR4A subfamily, acts as a gene regulator in a wide range of signaling pathways and responses to human diseases. Here, we provide a brief overview of the current functions of NR4A1 in human diseases and the factors involved in its function. A deeper understanding of these mechanisms can potentially improve drug development and disease therapy.

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Published In

cover image Biochemistry and Cell Biology
Biochemistry and Cell Biology
Volume 101Number 2April 2023
Pages: 148 - 159


Received: 1 November 2022
Accepted: 9 January 2023
Accepted manuscript online: 2 March 2023
Version of record online: 2 March 2023

Data Availability Statement

The datasets generated or analyzed during this study are available from the corresponding author on reasonable request.


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Key Words

  1. NR4A1
  2. function
  3. human disease
  4. molecular pathway



Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050091, China
Author Contributions: Conceptualization, Formal analysis, Resources, Visualization, and Writing – original draft.
Mengjuan Zhang
Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050091, China
Author Contributions: Data curation, Resources, and Writing – original draft.
Fang Fang
Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050091, China
Author Contribution: Resources.
Chang Xu
Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050091, China
Author Contribution: Resources.
Jiazhi Liu
Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050091, China
Author Contribution: Resources.
Lanjun Gao
Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050091, China
Author Contribution: Resources.
Chenchen Zhao
Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050091, China
Author Contribution: Resources.
Zheng Wang
Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns Research, Shijiazhuang 050091, China
Institute of Integrative Medicine, College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang 050200, China
Author Contribution: Writing – review & editing.
Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns Research, Shijiazhuang 050091, China
Institute of Integrative Medicine, College of Integrative Medicine, Hebei University of Chinese Medicine, Shijiazhuang 050200, China
Author Contributions: Conceptualization and Supervision.
Hebei Key Laboratory of Integrative Medicine on Liver-Kidney Patterns Research, Shijiazhuang 050091, China
Author Contributions: Conceptualization, Funding acquisition, and Supervision.

Author Contributions

Conceptualization: HW, YZ, XW
Data curation: MZ
Formal analysis: HW
Funding acquisition: XW
Resources: HW, MZ, FF, CX, JL, LG, CZ
Supervision: YZ, XW
Visualization: HW
Writing – original draft: HW, MZ
Writing – review & editing: ZW

Competing Interests

The authors declare that they have no conflict of interest.

Funding Information

This study was funded by Key Program of Hebei Natural Science Foundation of Traditional Chinese Medicine, H2022423351, and Science and Technology Planning Project of Hebei Provincial Science and Technology Department, 20277714D.

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