Cookies Notification

We use cookies to improve your website experience. To learn about our use of cookies and how you can manage your cookie settings, please see our Cookie Policy.
×

THE EFFECTS OF A CARDIAC GLYCOSIDE ON SUBCELLULAR STRUCTURES WITHIN NERVE CELLS AND THEIR PROCESSES IN SYMPATHETIC GANGLIA AND SKELETAL MUSCLE

Publication: Canadian Journal of Biochemistry and Physiology
February 1962

Abstract

Nerve cells and their processes in cat sympathetic ganglia and frog skeletal muscle have shown on electron microscopic examination alterations in subcellular morphology as a result of treatment with digoxin. Non-nervous cells were unaffected by the drug. These changes included, in ganglia, swelling of the affected cells, shrinkage of mitochondria with pronounced increase in internal density, swelling of Nissl substance in nerve cell bodies, and loss of structural detail in nerve processes. At the myoneural junction the motor nerve endings were swollen, mitochondria were altered, and the synaptic vesicles were reduced in numbers, those that remained being swollen. These changes were accompanied by invagination of the axon surface by Schwann cell processes.Cell swelling, but not the subcellular changes, was prevented by substitution of sulphate for chloride ions in the extracellular space. When the extracellular sodium ion concentration was reduced to 20 meq/l. the cells were completely protected against digoxin. It is concluded that swelling is caused by net uptake of sodium and chloride as a result of the known inhibitory action of digoxin on sodium extrusion by nerve cells. The possibility that these structural changes in subcellular organelles may be caused by a raised concentration of intracellular sodium ions, such as might occur during activity of excitable cells, is discussed.

Résumé

non disponible

Get full access to this article

View all available purchase options and get full access to this article.

Information & Authors

Information

Published In

cover image Canadian Journal of Biochemistry and Physiology
Canadian Journal of Biochemistry and Physiology
Volume 40Number 2February 1962
Pages: 303 - 315

History

Version of record online: 2 February 2011

Permissions

Request permissions for this article.

Authors

Affiliations

Metrics & Citations

Metrics

Other Metrics

Citations

Cite As

Export Citations

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

Cited by

1. Mobilization of a Vesamicol‐Insensitive Pool of Acetylcholine from a Sympathetic Ganglion by Ouabain
2. Chapter 21: Storage and release of acetylcholine in a sympathetic ganglion
3. Digoxin uptake into peripheral autonomic cardiac nerves: Possible mechanism of digitalis-induced antiarrhythmic and toxic electrophysiologic actions
4. Blockage of depolarization-induced mitogenesis in CNS neurons by 5-fluoro-2′-deoxyuridine
5. Structure of the Synapse
6. The relationship of transmitter release and storage to fine structure in a sympathetic ganglion
7. Morphological, biochemical, and functional changes in chick embryonic brain tissue after intracerebral administration of ouabain
8. Effects of Bufalin and Related Cardiotonic Steroids in the Neuromuscular Junction
9. Distribution of Cerebral Fluids and Electrolytes In Vivo and In Vitro
10. FLUID COMPARTMENTATION AND ELECTROLYTES OF CAT CEREBRAL CORTEX IN VITRO –I SWELLING AND SOLUTE DISTRIBUTION IN MATURE CEREBRAL CORTEX*
11. Determination of transmembrane water movement in crustacean axons by interference microscopy
12. Problems associated with Studies of Electrolyte Metabolism in Normal and Epileptogenic Cerebral Cortex
13. Arrest of Seizure Activity Biochemical Aspects and Pharmacology
14. THE ROLE OF SODIUM IONS IN THE RELEASE OF ACETYLCHOLINE
15. The Distribution of Water in Brain Tissues Swollen in vitro and in vivo
16. SYNTHESIS AND STORAGE OF ACETYLCHOLINE IN NERVOUS TISSUE
17. SYNTHESIS AND STORAGE OF ACETYLCHOLINE IN NERVOUS TISSUE

View Options

Get Access

Login options

Check if you access through your login credentials or your institution to get full access on this article.

Subscribe

Click on the button below to subscribe to Canadian Journal of Biochemistry and Physiology

Purchase options

Purchase this article to get full access to it.

Restore your content access

Enter your email address to restore your content access:

Note: This functionality works only for purchases done as a guest. If you already have an account, log in to access the content to which you are entitled.

View options

PDF

View PDF

Media

Media

Other

Tables

Share Options

Share

Share the article link

Share on social media