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Dietary restriction and fibre supplementation: oxidative stress and metabolic shifting for cardiac health

Publication: Canadian Journal of Physiology and Pharmacology
November 2003

Abstract

Dietary modification ought to be the first line of strategy in prevention of the development of cardiac disease. The purpose of this study was to investigate whether dietary restriction, dietary-fibre-enriched diet, and their interactions might affect antioxidant capacity and oxidative stress in cardiac tissue. Male Wistar rats (180–200 g; n = 10) were divided into four groups: control ad libitum diet (C), 50% restricted diet (DR), fed with fibre-enriched diet (F), and 50% restricted fibre-enriched diet (DR-F). After 35 days of the treatments, F, DR, and DR-F rats showed low cholesterol, LDL-cholesterol, and triacylglycerol, and high HDL-cholesterol in serum. The DR, DR-F, and F groups had decreased myocardial lipoperoxide and lipid hydroperoxide. The DR-F and F treatments increased superoxide dismutase and glutatione peroxidase (GSH-Px). The DR treatment increased GSH-Px and catalase activities. Dietary fibre beneficial effects were related to metabolic alterations. The F and DR-F groups showed high cardiac glycogen and low lactate dehydrogenase/citrate synthase ratios, indicating diminished anaerobic and elevated aerobic myocardial metabolism in these animals. There was no synergistic effect between dietary restriction and dietary fibre addition, since no differences were observed in markers of oxidative stress in the F and DR-F groups. Dietary fibre supplementation, rather than energy intake and dietary restriction, appears to be the main process retarding oxidative stress in cardiac tissue.Key words: dietary fibre, dietary restriction, cardiac tissue, oxidative stress.

Résumé

Une modification de l'alimentation doit être la stratégie de première ligne pour prévenir l'apparition des maladies cardiaques. La présente étude a eu pour but d'examiner si une restriction alimentaire, un régime enrichi en fibres et leurs interactions peuvent influer sur la capacité antioxydante et le stress oxydatif dans le tissu cardiaque. Des rats Wistar mâles (180–200 g; n = 10) ont été répartis dans quatre groupes : ad libitum témoin (T), restriction alimentaire de 50% (RA), régime enrichi en fibres (F) et régime enrichi en fibres avec restriction alimentaire de 50% (RA-F). Après 35 jours de traitement, le sérum des rats F, RA et RA-F a montré un faible taux de cholestérol, du cholestérol-LDL, des triacylglycérols et du cholestérol-HDL. La teneur en lipoperoxyde myocardique et en hydroperoxyde lipidique des groupes RA, RA-F et F a diminué. Le taux de superoxyde dismutase et de glutathion peroxydase (GSH-Px) des groupes RA-F et F a augmenté. La teneur en GSH-Px et en catalase du groupe RA a augmenté. Les effets bénéfiques du régime F ont été associés à des modifications métaboliques. Les groupes F et RA-F ont montré un taux élevé de glycogène cardiaque et un rapport lactate déshydrogénase/citrate synthase faible, indiquant une diminution du métabolisme myocardique anaérobie et une augmentation du métabolisme myocardique aérobie chez ces animaux. Il n'y a pas eu d'effet synergique sur les régimes RA et enrichi en fibres, aucune différence n'ayant été observée sur les marqueurs de stress oxydatif chez les groupes F et RA-F. La supplémentation en fibres alimentaires, davantage que l'ap port énergétique et la restriction alimentaire, semble être la principale mesure pour ralentir le stress oxydatif dans le tissu cardiaque.Mots clés : fibre alimentaire, restriction alimentaire, tissu cardiaque, stress oxydatif.[Traduit par la Rédaction]

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cover image Canadian Journal of Physiology and Pharmacology
Canadian Journal of Physiology and Pharmacology
Volume 81Number 11November 2003
Pages: 1042 - 1048

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Version of record online: 13 February 2011

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